Tyrosine - karolo ea 'mele le litšobotsi tse ntle tsa amino acid

Tyrosine ke aminocarboxylic acid e hlokahalang maemong a itseng e amehang katabolism le anabolism, ho kenyeletsoa le protheine ea mesifa, dopamine le li-neurotransmitters. E thehiloe ho phenylalanine.

Mochine oa synthesis oa Tyrosine

Tsela e matla ea tyrosine ke C₉H₁₁NO₃, phenylalanine ke C₉H₁₁NO₂. Tyrosine e thehiloe ho latela morero o latelang:

C₉H₁₁NO₂ + phenylalanine-4-hydroxylase => C₉H₁₁NO₃.

Litlamorao tsa tlhaho ea tyrosine

Kamoo tyrosine e amang 'mele le hore na e etsa mesebetsi efe:

• e sebetsa e le sesebelisoa sa polasetiki bakeng sa sebopeho sa melanin, lihormone tsa catecholamine kapa catecholamines (adrenaline le norepinephrine, dopamine, thyroxine, triiodothyronine, L-dioxyphenalalanine), li-neurotransmitters le li-neurotransmitters;
• e nka karolo mosebetsing oa qoqotho le litšoelesa tsa adrenal;
• e hlahisa mamello tlasa khatello ea maikutlo, e khothaletsa ho hlaphoheloa kapele;
• e na le phello e ntle ts'ebetsong ea sistimi ea methapo le lisebelisoa tsa vestibular;
• e rata ho tlosa 'mele;
• bontša ketso ea ho imeloa kelellong;
• e eketsa ho tsepamisa mohopolo kelellong;
• nka karolo phapanyetsano mocheso;
• e hatella catabolism;
• ho imolla matšoao a lefu la pele ho khoeli.

Ts'ebeliso ea tyrosine bakeng sa boima ba 'mele

Ka lebaka la bokhoni ba eona ba ho ntlafatsa ts'ebeliso ea mafura, L-tyrosine e sebelisoa nakong ea ho omisoa (boima ba 'mele) tlasa taolo ea ngaka ea lipapali.

Ho hlokahala tyrosine e kae ka letsatsi

Tekanyo ea letsatsi le letsatsi ea tyrosine e tloha ho 0.5-1.5 dikgerama, ho latela maemo a kelello le maikutlo. Ho nka amino acid nako e fetang likhoeli tse 3 tse latellanang ha ho khothaletsoe. Ho molemo ho ja le metsi ka hanyane.

Bakeng sa ho ntlafatsa phello ea kalafo, tyrosine e khothalletsoa hore e sebelisoe hammoho le methionine le livithamini B6, B1 le C.

Ho haella le ho feta ha tyrosine, matšoao le litlamorao

Ho feteletseng (hypertyrosinosis kapa hypertyrosinia) kapa khaello (hypothyrosinia kapa hypothyrosinosis) ea amino acid tyrosine 'meleng e ka lebisa ho mathata a metabolism.

Matšoao a ho fetella le khaello ea tyrosine ha a totobetse, ho etsang hore ho be thata ho fumana lefu lena. Ha u etsa tlhahlobo ea mafu, ho bohlokoa ho ela hloko lintlha tsa anamnestic (tse fetisitsoeng bosiung ba lefu lena, ho noa meriana, ho ja lijo).

Tse ngata

Ho fetella ha tyrosine ho ka iponahatsa e le ho se leka-lekane mosebetsing:

• litšoelesa tsa adrenal;
• tsamaiso ea methapo ea bohareng le ea pheriferale;
• tšoelesa ea qoqotho (hypothyroidism).

Bothata

Khaello ea amino acid e tšoauoa ka matšoao a latelang:

• mosebetsi o eketsehileng ho bana;
• khatello e tlase ea mali (khatello ea mali);
• fokotseha mocheso oa 'mele;
• thibelo ea tšebetso ea 'mele le kelello ho batho ba baholo;
• bofokoli ba mesifa;
• ho tepella maikutlo;
• ho fetoha ha maikutlo;
• boima ba 'mele ka lijo tse tloaelehileng;
• lefu la maoto le sa phomole;
• ho lahleheloa ke moriri;
• ho robala ho eketsehileng;
• ho fokotsa takatso ea lijo.

Ho haella ha Tyrosine ho ka bakoa ke ho haelloa ke lijo tse nang le lijo kapa sebopeho se sa lekanang ho tsoa ho phenylalanine.

Hypertyrosinosis e khetholloa ka karolo e 'ngoe ke keketseho e matlafatsang ea tlhahiso ea thyroxine (lefu la Graves):

• ho fokotseha ho bonahalang ha boima ba 'mele;
• khathatso ea boroko;
• thabo e eketsehileng;
• ho tsekela;
• ho tšoaroa ke hlooho;
• tachycardia;
• matšoao a dyspeptic (ho hloka takatso ea lijo, ho nyekeloa ke pelo, ho nyekeloa ke pelo, ho hlatsa, ho eketsa acidity ea lero la ka mpeng, hyperacid gastritis kapa gastric kapa duodenal ulcer).

Litlhaloso

Litokisetso tsa Tyrosine ha li khothalletsoe hore li sebelisoe le:

• ho hloka mamello kapa ho hanana le likarolo tsa tlatsetso kapa lithethefatsi;
• mafu a qoqotho (hyperthyroidism);
• bokuli ba kelello (schizophrenia);
• lefa la tyrosinemia;
• kalafo ka MAO (monoamine oxidase) inhibitors;
• Lefu la Parkinson.

Litla-morao

Litla-morao li fapane 'me ha li khethoe feela ke litšobotsi tsa motho, empa hape le mefuta e fapaneng ea liphetoho tsa lik'hemik'hale, moo aminocarboxylic acid e amehang. Ntlheng ena, e le ho li thibela, ho kgothaletswa ho qala ho nka amino acid le litekanyetso tse tlase tlasa taolo ea ngaka e eang teng.

Litla-morao tse atileng haholo li kenyelletsa arthralgia, hlooho, ho otloa ke pelo le ho nyekeloa ke pelo.

Ho sebelisana

Phetoho ea phello ea meriana ea tyrosine ha e qheleloe ka thoko ha e sebelisoa hammoho le joala, li-opiate, li-steroid kapa li-supplement tsa lipapali. Ntlheng ena, ho eletsoa ho eketsa palo ea lithethefatsi tse nooang hanyane ka hanyane, e le hore, ha ho hlokahala, ho kenyelletsa motswako o sa rateheng.

Lijo tse nang le Tyrosine

Amino acid e fumanoa nameng ea liphoofolo tse anyesang, linonyana le litlhapi, linaoa tsa soya, matokomane, lihlahisoa tsa lebese, linaoa, koro, oatmeal, lijo tsa leoatleng, lijo tse ling.

Phepo ea lipapali le L-tyrosine

L-Tyrosine e fumaneha ka matlapa a 1100 mg le 400 mg, 500 mg kapa li-capsules tsa 600 mg. Pitsa e le 1 ea polasetiki e na le matlapa a 60, kapa li-capsules tse 50, 60 kapa 100. Microcrystalline cellulose, aerosil le Mg stearate li sebelisoa e le ho tlatsa.

Theko ea k'hemisteng bakeng sa li-capsules tse 60 tsa 500 mg e ka har'a li-ruble tse 900-1300.

Kopo le tekanyetso

Tlhoko ea letsatsi le letsatsi ea tyrosine ho motho e moholo ke 25 mg / kg (1.75 g / ka letsatsi). Tekanyo e ka fapana ho latela sepheo sa ho sebelisa ntho eo (e khethiloeng ke ngaka e eang teng).

Ho kgothaletswa ho hlapolla lihlahisoa le tyrosine ka apole kapa lero la lamunu.

Shebella video: Amino Acid Biosynthesis. Biosynthesis of Tryptophan (July 2025).